Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. Other drugs may interact with milk thistle, including prescription and over-the-counter medicines, vitamins, and herbal products. Abstract Allergic asthma is a chronic inflammatory disease regulated by coordination of T-helper2 (Th2) type cytokines and inflammatory signal molecules. FOIA J Diabetes Res. Here are 7 science-based benefits of milk thistle. All rights reserved. Drug class: Herbal products. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. In clinical trials, milk thistle appears to be well tolerated in recommended doses. One study questioned the benefits of milk thistle for liver diseases. Available for Android and iOS devices. To provide you with the most relevant and helpful information, and understand which Pizzorono JE, et al., eds. Dosage and side effects. Receive the latest, most useful health and wellness articles, tips, special discounts on nutritional supplements and so much more. Its regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer (1, 5, 6). Mayo Clinic does not endorse companies or products. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. Historically, people have used milk thistle for liver disorders and gallbladder problems. Milk thistle is often sold as an herbal supplement. JAMA. This site needs JavaScript to work properly. I'm looking forward to my blood results. Milk thistle can trigger allergic reactions. Summary Milk thistle may increase breast milk production in women who are lactating, though very little research has been done to confirm its effects. BDNF-TrkB pathway mediates antidepressant-like roles of H. New insights into BDNF function in depression and anxiety. While milk thistle is considered a noxious weed in various parts of the United States, it has little oral consumption value and is best absorbed in tablet or capsule supplement form, but can also be consumed as a tea or oral tincture. 2005 - 2023 WebMD LLC, an Internet Brands company. Milk thistle. Milk thistle may not be safe for everyone. JAMA. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Epub 2016 Mar 9. Silymarin is an active component of milk thistle, which is not found in foods. Can You Get Milk Thistle Naturally From Foods? Some people are advised to be cautious when taking milk thistle. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. These side effects may be mild or severe. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). Milk thistle's main active component is silymarin which works by normalizing levels of both serotonin and dopamine. Its main functions include antioxidant . Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887, Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. IBM Micromedex. 2022 Nov 29;23(23):14968. doi: 10.3390/ijms232314968. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. The nutritional content varies for each brand, so be sure to . Milk thistle (PDQ): Health Professional Version. . Due to its antioxidant and anti-inflammatory effects, milk thistle may be a useful supplement for people with acne. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. 2008;47(2):605-12. doi:10.1002/hep.22044, Voroneanu, L.; Nistor, I.; Dumea, R. et al. eCollection 2022. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. Milk thistle has a distinctive purple flower and spiky leaves, grows to about 200 cm in height, and is found throughout the world. 2023 May;475(5):621-635. doi: 10.1007/s00424-023-02795-y. Tadaah, perhaps a partly explanation for your experience? This article will explore the uses of milk thistle and research on its potential benefits. All rights reserved. 2018;8:65-74. doi:10.2147/PTT.S169333. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Written by Cerner Multum. What Are the Side Effects of Milk Thistle? 1982;17:51721. Side effects are always possible when taking supplements. They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition (21). Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. To ensure quality and potency in your herbal remedies, why not grow your own? Summary In animals, milk thistle has been shown to stimulate bone mineralization. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. Protective Effect of Silibinin on Learning and Memory Impairment in LPS-Treated Rats via ROS-BDNF-TrkB Pathway. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums. ; Extensively studied; effective in treatment of cirrhosis, hepatitis, chemical- or . Milk Thistle is used to treat alcoholic liver disease, gallbladder problems, hepatic cirrhosis, hepatitis (chronic), hepatotoxicity (chemical/drug-induced), jaundice, pleurisy, prostate cancer, and spleen diseases, and used as an appetite stimulant.. For example, in one study, researchers investigated the mood elevating effects of silymarin, a collection of phytochemicals extracted from milk thistle. Bookshelf Store at room temperature away from moisture, heat, and light. Do not use more of this product than is recommended on the label. Accessed Oct. 30, 2020. Occasionally, people report various digestive side effects. National Center for Complementary and Integrative Health. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Liu HY, Wei HJ, Wu L, Liu SM, Tang YY, Zou W, Wang CY, Zhang P, Tang XQ. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. Milk thistle has not been shown to treat or prevent cancer or reduce the side effects of cancer treatment. There is no standardized dosage or recommended intake for milk thistle tea, but it's generally considered safe if consumed in moderation. This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Call your doctor if the condition you are treating with milk thistle does not improve, or if it gets worse while using this product. Natural Medicines. When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. Milk thistle can also be taken with cholesterol-lowering medications, like statins. Longe, J., ed. Unauthorized use of these marks is strictly prohibited. Users are advised to seek the advice of their physician or other qualified health care provider with any questions you may have regarding a medical condition. 8600 Rockville Pike 2023 Jan 26;15:997054. doi: 10.3389/fnmol.2022.997054. 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. Natural Medicines website. https://naturalmedicines.therapeuticresearch.com. National Cancer Institute PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. . Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Milk thistle is a plant also known as Artichaut Sauvage, Cardo Lechoso, Cardui Mariae, Carduus marianus, Chardon Argent, Chardon de Marie, pine Blanche, Holy Thistle, Lady's Thistle, Lait de Notre-Dame, Legalon, Marian Thistle, Mariendistel, Mary Thistle, Shui Fei Ji, Silibinin, Silybe de Marie, Silybum, Silymarin, and other names. Here are 10 of the best herbs for your liver, including benefits and. The Gale Encyclopedia of Alternative Medicine, second edition, 2004. This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. The benefits of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. An official website of the United States government. Learn. Milk thistle is taken by mouth most often for liver disorders, including liver damage caused by chemicals, alcohol, and chemotherapy, as well as liver damage caused by Amanita phalloides (death cap) mushroom poisoning, jaundice, chronic inflammatory liver disease, cirrhosis of the liver, and chronic hepatitis. Accessed Oct. 30, 2020. In one clinical trial, 60 people with benign polyps in the colon (which often develop into colon cancer) took a herbal blend with milk thistle, a flaxseed antioxidant, and oat fiber for 2 . In: Textbook of Natural Medicine. Milk thistlesupplementscontaining silymarin are commonly sold as teas or in capsule form, but are also available as tablets, soft gels, and liquid extracts. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. In fact, a recent review and analysis found that people routinely taking silymarin experienced a significant reduction in their fasting blood sugar levels and HbA1c, a measure of blood sugar control (44). The following list is not exhaustive. Hepatology. However, how it affects humans is currently unknown. In reducing oxidative stress, milk thistle is believed to be neuroprotective by helping prevent decline in brain function. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. PMC Milk thistle should not be used in place of medication prescribed for you by your doctor. Risks. Also known as Silybum marianum, milk thistle is a perennial herb native to many continents and countries across the globe, including Southern Europe, Southern Russia, Asia Minor, Northern Africa, and the Americas. Anticancer Drugs. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. However, its currently unclear if it has the same beneficial effects in humans. Seeff, L.; Curto, T.; Szabo, G. et al. However, research is not conclusive on its uses. Milk thistle has long been utilized as an anti-inflammatory agent offering numerous benefits to our liver, cholesterol, cardiovascular health, menopause symptom relief, and even gallbladder disorders. Quality and active ingredients in supplements may vary widely from maker to maker. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Although some studies have shown positive results on milk thistle for people with chronic hepatitis C virus (HCV) infection, the overall research does not show a benefit. Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. . Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). It can help prevent elevation of liver enzymes, which can be a side effect of the medication. However, there are currently no human studies, so its effectiveness remains unclear. Milk thistle may also be used for purposes not listed in this product guide. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). Liver Detoxification and Health. Milk thistle may be useful in treating liver disease, cancer, and diabetes. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Its thought to work by making more of the milk-producing hormone prolactin. Epub 2013 Oct 14. Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. Abdulghani A, Poghosyan M, Mehren A, Philipsen A, Anderzhanova E. Front Mol Neurosci. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. Medically reviewed by Drugs.com on Sep 29, 2022. People with diabetes often have high cholesterol. privacy practices. After using 2 tablets a day and 1 month, indigestion and pain in my liver disappeared. Milk thistle is not recommended for children. edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. While not dangerous, it can cause scars. Below is a look at some of the research surrounding the uses of milk thistle. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). One small clinical trial showed an increase in breast milk formation in humans using milk thistle, but researchers caution that more studies are needed. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. There is not enough scientific data to say whether or not milk thistle can help liver problems. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. Fluoxetine (Prozac), for instance, clocks in at roughly $16 for 21 capsules if youre buying with the drugs.com discount card, but the side effects are often not as easy to swallow (3). (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Milk thistle may not be recommended in some situations. It is not intended to substitute for the medical expertise and advice of your health care provider(s). The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. However, as this is the only study, more high-quality research is needed. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Eighteen clinical trials of 1,088 participants were assessed. In a mini Review on the Chemistry and Neuroprotective Effects of Silymarin, published in 2017, researchers went so far as to say that silymarin promotes the inhibition of the inflammatory response generated during neurodegeneration.. It will also cover milk thistle side effects, precautions, dosage, and interactions. "It helps to clear out the toxins and nourish the organ," says Justice. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. doi:10.1002/14651858.CD003620.pub3, Gillessen A, Schmidt HH. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. Thats an alarmingly high percentage, leaving roughly 1.1 million people of the 2.2 million OCD sufferers in the United States seeking alternative treatment options (2) and natural remedies. Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Satisfaction. 2020;31(4):/j/jbcpp.2020.31.issue-4/jbcpp-2019-0206/jbcpp-2019-0206.xml. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Theres conflicting research on the benefits of milk thistle for liver health. What Is Complementary, Alternative, or Integrative Health? Milk thistle is often promoted for its liver-protecting effects. https://www.nccih.nih.gov/health/milk-thistle. Silibinin significantly attenuated anxiety/depression-like behaviors caused by A1-42-treatment as shown in tail suspension test (TST), elevated plus maze (EPM) and forced swimming tests (FST). Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. Swimming and L-arginine loaded chitosan nanoparticles ameliorates aging-induced neuron atrophy, autophagy marker LC3, GABA and BDNF-TrkB pathway in the spinal cord of rats. Exercise caution and start slow. Accessibility This publication is not copyrighted and is in the public domain. Together, you can make shared, well-informed decisions. However, the evidence is conflicting. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. J Med Assoc Thai. Acne is a chronic inflammatory skin condition. Is There a Reason Your Milk Thistle Isn't Working? Additionally, the antioxidant and anti-inflammatory properties of milk thistle may also be useful for reducing the risk of developing diabetic complications like kidney disease (43). information submitted for this request. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. information highlighted below and resubmit the form. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Milk thistle is currently used for the treatment of toxin-induced liver injury, for its inhibition of progressive hepatic fibrosis and the prevention of cirrhosis, for its antifibrogenic effects in alcohol-induced cirrhosis and for modulation of insulin resistance. Federal government websites often end in .gov or .mil. However, there is no solid evidence that supports these claims. Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Neurochem Res. Unable to load your collection due to an error, Unable to load your delegates due to an error. Trigonella foenum-graecum(fenugreek)also is used for this reason. By Brittany Lubeck, RD Review/update the It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, Silybin and the liver: from basic research to clinical practice, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies. Historically, people have used milk thistle for liver disorders and gallbladder problems. Milk thistle is promoted as a dietary supplement for . Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut-Brain Axis. We comply with the HONcode standard for trustworthy health information. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. *These statements have not been evaluated by the Food and Drug Administration. 2016 Jul;41(7):1662-72. doi: 10.1007/s11064-016-1881-5. Int J Mol Sci. Milk thistle products appear to help the skin heal from damage caused by UVB radiation from the sun and may offer benefits in preventing non-melanoma skin cancers. Effects of Silybum marianum (L.) Gaertn. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. a history of endometriosis or uterine fibroids. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. If you take any medicines regularly, talk to your doctor before you start using milk thistle. Malaria. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. 2016;5147468. doi:10.1155/2016/5147468. However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin (1). Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments. Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Clin Exp Pharmacol Physiol. Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. These include: Summary Milk thistle is generally considered safe. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. Research shows that the silymarin in milk thistle helps protect the liver from many industrial toxins, such as carbon tetrachloride. 2016;68(4):1026-1073. doi:10.1124/pr.115.010843. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Milk thistle may produce allergic reactions, which tend to be more common among people who are allergic to plants in the same family (for example, ragweed, chrysanthemum, marigold, and daisy). Duplication is encouraged. However, many of these potential benefits are not backed by science. Click here for an email preview. If you are a Mayo Clinic patient, this could Zargani M, Ramirez-Campillo R, Arabzadeh E. Pflugers Arch. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. Uses of Lavender: Everything You Need to Know, 11 Popular Natural Remedies for the Common Cold, Natural Remedies for Alcohol Use Disorder, The therapeutic potential of milk thistle in diabetes, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. health information, we will treat all of that information as protected health Milk thistle is generally considered safe when taken by mouth (1, 45). (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Botanicals and their bioactive phytochemicals for women's health, Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review, Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. . information is beneficial, we may combine your email and website usage information with Taken in appropriate doses, oral use of milk thistle appears to be safe. Reflux Risk and Relief View More . . It is possible to take too much, and liver toxicity has been observed in people with cancer taking silybin at very high doses (10 to 20 grams per day). Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y, Seeff LB, Curto TM, Szabo G, et al. There is also concern that milk thistle might affect estrogen levels. Salmi, H. and Sarna, S. Effect of silymarin on chemical, functional, and morphological alterations of the liver. As a result of excessive alcohol consumption, my liver was fattened and my enzymes increased. Effects of Silybum marianum (L.) Gaertn. People with diabetes should use caution. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. benefits of tithing kenneth copeland, owensboro public schools jobs, wyoming district court judges,
