Announcement of the national health and Health Commission of the people's Republic of China [EB /OL] (2020-01-20) [20200217]. If use with the other drugs at the same time may occur drug interactions,details please consult your physician or pharmacist. It is compatible with Rhodiola to clear lung and remove blood stasis. WebAs chemical analysis for quality control (QC) of traditional Chinese medicine (TCM) formula is difficult to guarantee the effectiveness, a bioassay method that combines QC with evaluation of therapeutic effects has been developed to assess the TCM quality. Meanwhile, China also provides technical solutions through long-distance video exchanges to share treatment experience with Japan, South Korea, Italy, the United States, Iran, Singapore, and so on. The https:// ensures that you are connecting to the Drug discoveries & therapeutics 2020;14:6772. [36]. V03AX - Other therapeutic products ; Other products with therapeutic properties. Lianhua Qingwen combined with conventional drugs may be a promising therapy for treating common pneumonia and COVID-19 pneumonia. WhileDDB notes the FDAs approvalofLHQWas a traditional herbal product that may helprelievefever, muscle soreness, stuffy and runny nose associated with Covid-19, the DDBalsobelievesinpreventing diversion and unsafe use and abuseof this product withouthampering theaccess toit. System searches CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as ChiCTR, NTR and clinical Trials.gov. Second Prize of National Science and Technology Progress Awards The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. First case of 2019 novel coronavirus in the United States. Hongying Mo, Changwen Ke, Jinping Zheng, et al. Lianhua Qingwen (LHQW) Bookshelf Lu Y, Zhang M, Yang QQ, Li WJ, Yang K, Hu W, Gao SY, Jiang QL, Lin LK, Cheng H, Sun F. Evid Based Complement Alternat Med. Treatment of Pediatric Diseases, 2017, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2016, the Phase II Clinical Trial for Lianhua Qingwen approved by US FDA started in Virginia in the US in September, 2015, recognized as a recommended product in the Expert Consensus Document on Treatment of Cold in Special Populations, 2015, recognized as a recommended product in the Standard Therapy for Middle East Respiratory Syndrome, 2014, recognized as a recommended product in the Standard TCM Therapy for Ebola Virus Infections, 2014, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Expert Consensus Document on Medical Rescuing of Human Beings Infected by H7N9 Avian Influenza, 2013, recognized as a recommended product in the Standard Therapy for Human Beings Infected by H7N9 Avian Influenza, 2012, recognized as a recommended product in the Standard TCM Therapy for Influenza B Virus Infections, 2011, recognized as a recommended product in the Guideline on Diagnosis and Treatment of Influenza, 2010, recognized as a recommended product in the Standard Therapy for Rheumatic Fever (Non-severe Community Acquired Pneumonia), 2009, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Influenza A H1N1, 2008, recognized as a recommended product in the Instructions on Use of TCM Therapies for Prevention and Treatment of Diseases after an Earthquake, 2008, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza (2008), 2005, recognized as a recommended product in the Standard Therapy for Human Beings Infected by Avian Influenza, [Drug Name]Generic name: Lianhua Qingwen Capsules. She can be reached atbandiolateresamayb@gmail.com. One box of LHQW last 2 days and 4 boxes last 8 days. Keyword Highlighting Wang DC, Yu M, Xie WX, Huang LY, Wei J, Lei YH. 2018;Beijing: Science and Technology Literature Press, 13271329. V03AX - Other therapeutic products ; Other products with therapeutic properties. This site needs JavaScript to work properly. Patients with body temperature higher than 38.5 should see the doctor. 2023. Children should be administered under adults supervision. and transmitted securely. Wu C, Chen X, Cai Y, et al. Do not give during pregnancy & lactation, & in childn. However, this systematic review will have some limitations. In addition, Manual retrieval of articles, conference papers, ongoing experiments, internal reports, among others, to supplement electronic retrieval. LHQW is not approved by Singapore's HSA for the prevention and treatment of Covid-19. modify the keyword list to augment your search. All randomized controlled trials (RCTs), Retrospective cohort study (RCSs), Comparison before and after the study (BAs) of Lianhua Qingwen combined with Conventional antiviral Western Medicine for COVID-19 will be included. For novel coronavirus pneumonia, the total effective rate of TCM is over 90%.[EB/OL]. 12th-Five Year Plan Special Project of National Major New Drug Development Nausea, vomiting, abdominal pain, diarrhea, bloating. Correspondence: Mingjun Liu, and Xiaolin Zhang, professor, Changchun University of Chinese Medicine, 1035 Boshuo Road, Jingyue Economic Development Zone, Changchun City, Jilin Province 130117, China (e-mail: [emailprotected], [emailprotected]). Cao B, Wang Y, Wen D, et al. Choosing a selection results in a full page refresh. COVID-19; Lianhua Qingwen; meta-analysis; protocol; systematic review. MJL will arbitrate any disagreement and ensure that no errors occur during the review. If meta-analysis is not applicable, we will conduct a systematic narrative synthesis providing information to summarize and explain the characteristics and findings of the included studies. WebLianhua Qingwen Dosage & Drug Information | MIMS Thailand Lianhua Qingwen(Forsythiae fructus 225 mg, Lonicerae japonicae flos 225 mg, Ephedrae herba Hai Guo, Jin Yang, Jiening Gong, et al. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Post code: 050035 Tel: 0086-311-85901643 Fax: 0086-311-85906730 Website: http://www.yiling.cn Any questions or problems, please do not hesitate to contact manufacturer. All review authors critically reviewed, revised and approved the subsequent and final version of the protocol. 11. Coronavirus disease 2019 (, [5]. We may also contact the original authors to provide additional relevant information, if necessary. It is used for temporary relief of shortness of breath, chest tightness, and wheezing due to bronchial asthma. It is based on the published clinical research literature at present stage. [18]. Philippines FDA approved LHQW for the treatment of mild Covid-19. Your message has been successfully sent to your colleague. Receive exclusive coupons and special offers directly to your email inbox. Should not be used for wind-cold common cold. Aside from the Philippines, the Lianhua Qingwen Capsule has been approved in Hong Kong and Macau, Brazil, Indonesia, Canada, Mozambique, Romania, Thailand, Ecuador, Singapore and Lao. [21]. 5.Children, preganant or lactation women,elderly ,feeble and weak patients ,spleen and stomach weakness patients should be taken under the guidance of physician. If I2 test <50%, a fixed-effects model will be used to pool the data. Also illustrates the potential biases within each of the included studies by presenting a risk of bias," table, graph, and summary. Remdesivir in adults with severe, [13]. National Class- A Varieties for Medical Insurance Drugs The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function[J]. According to the Cochrane Handbook bias risk assessment tool, bias risk is independently assessed. Correct way is to take it orally, 3 capsules 1 time, 3 times a Whats more,afterFDAslaboratory analysisof LHQW,itwas found tocomprise only 9.14 milligrams of ephedra extract and not the previously claimed85 milligrams onitsproduct indication. [Description]Capsules, containing tan to brown granule and powder; odour, slightly aromatic; taste, slightly bitter. Efficacy and safety of Lianhua Qingwen combined with conventional antiviral Western Medicine in the treatment of coronavirus disease (covid-19) in 2019: Protocol for a systematic review and meta-analysis. Effect of Lianhuaqingwen Capsule on lung index of mice infected with virus [J]. 2022 Aug 19;27(16):5292. doi: 10.3390/molecules27165292. Because the epidemic situation is still ongoing, there are still clinical studies in progress. Ephedra was banned from the Olympics and other sport events, even in the US military. 10 In 2017, Diagnosis and Treatment Scheme for Patients Infected with H7N9 Avian Influenza (Version 1)(2017) , issued by the National Health and Family Planning Commission There are no comments yet. WebTo evaluate the efficacy and safety of Lianhua Qingwen capsule for influenza. 8600 Rockville Pike The Chinese medicine compound Lianhua Qingwen has been listed as the recommended drug for the diagnosis and treatment of respiratory infectious diseases by doi: 10.1097/MD.0000000000021404. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. Experimental study of Lianhuaqingwen capsule against influenza A virus in vitro [J]. Early Treatment>14 years & above:4capsules x 3 times a day ( after breakfast, lunch and dinner) for7 to 10 days. The clinical effective rate, CT improvement rate, and severe conversion rate will be assessed as the primary outcomes. WebDosage/Direction for Use 4 cap tid w/ warm water. Medicine (Baltimore). You may search for similar articles that contain these same keywords or you may [2]. Yuewen Ding, Lijuan Zeng, Runfeng Li, et al. In comparison with the control group, 1) the total effective rate was significantly higher in the observation group (P<0.05); 2) the disappearance rates of fever, cough and fatigue were statistically higher in the observation group; 3) the treatment time was significantly shorter and patient recovery was significantly better in the observation group; 4) the laboratory index levels [white blood cell (WBC), interleukin-6 (IL-6), serum amyloid A (SAA)] were better in the observation group. Sofia Tomacruz covers defense and foreign affairs. There are an increasing number of studies on for COVID-19 published with inconclusive results in recent. [20]. 6.Patients with fever over 38.5 , should go to the hospital. It cannot be bought over-the-counter and not recommended for self-medication. Clearing away heat toxic materials,open the inhibited lung-energy and clearing away lung heat. National Library of Medicine In particular, theChinese herbma huang, scientifically known asEphedra sinica, is where the drug ephedrine is extracted from. Ahsan W, Javed S, Bratty MA, et al. FOIA Wenwen Cui, Xin Jin, Yanfen Zhang, et al. The following electronic bibliographic databases will be searched to identify relevant studies: CNKI, CBM, VIP and Wanfang databases, PubMed, EMBASE, MEDLINE, Cochrane central, and clinical trial registration centers, such as China Clinical Trial Registration Center (ChiCTR), Netherlands National Trial Registration Center (NTR) and clinical trials.gov. All tests are 2-tailed, and P < .05 is considered statistically significant. - China reported 11 new infections of the coronavirus on March 14, and for the first time since the start of the epidemic the majority of them were imported cases from overseas. Clipboard, Search History, and several other advanced features are temporarily unavailable. A funnel plot will be constructed and examined to assess publication bias and possible small study biases if the group include more than 10 trials. 2023 Feb 17;2023:6028554. doi: 10.1155/2023/6028554. Chinese Journal of basic medicine of traditional Chinese medicine 2013;19:11335. Writing review & editing: Xiaolin Zhang. Also indicated for the symptoms of fever, cough, and fatigue caused by the mild and moderate coronavirus disease 2019 (COVID-19) in combination with standard of care. In addition, it can also interact with other compounds and herbs. For RCTs, the Cochrane Collaboration's tool for assessing risk of bias will be used; 2. Egger M, Davey Smith G, Schneider M, et al. The registered Chinese capsule Lianhua Qingwen that has been approved should have the FDAs labeling requirements written in English, Domingo said. Published by Wolters Kluwer Health, Inc. 1. general information: title, authors, year of publication, and Study area, average age, average course of disease and treatment time; 2. trial characteristics: design, duration of follow-up, method of randomization, allocation concealment, incomplete outcome data, blinding (patients, people administering treatment, outcome assessors); 3. intervention(s): intervention(s) (The dosage form of. Novel coronavirus pneumonia treatment plan issued by the national health and Health Committee, State Administration of traditional Chinese medicine (trial version sixth) [EB/OL]. Third, the capsule can shorten fever & coughting time. Removes heat-toxin invasion of the lungs, including symptoms eg, fever, aversion to cold, muscle soreness, stuffy & runny nose. [Drug Interactions]Interaction may appear if administered accompanied with other medicine, consult with doctors or pharmacists for details. eCollection 2020. Even Particularly, when ephedrine is combined with caffeine (coffee), itcan lead to significant cardiovascular, metabolic, and hormonal responses. Yizhu Wang, Hongtao Wang, Xue Han, et al. BMC Complement Altern Med 2017;17:130. Whether a fixed-effects or a random-effects model will be used depends on the results of I2 test for heterogeneity. Stage Food and Drug Administration Approval number:Z20040063. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsule are as follows: First, The 3 drugs and 3 parties in China have been effective in many countries around the world, and once again reveal the special advantages of the Chinese herbal medicine overall adjustment and multi target therapy, which suggests the application of Lianhua Qingwen granule. [Contraindications]Those who are allergic to this product and its ingredients should not take it. Conclusion: FDA Director General Eric Domingo likewise confirmed the approval of Lianhua Qingwen in a text message to Rappler on Wednesday afternoon. Journal of Guangzhou University of traditional Chinese medicine, 2016 33:5404. (4) intervention characteristics: Lianhua Qingwen in the treatment group (dosage form, dose, frequency, duration). Please enable it to take advantage of the complete set of features! Lianhua Qingwen formula is based on the theory of collateral disease, to reveal the law of transmission of respiratory infectious diseases caused by virus. Nguyen HT, Do VM, Phan TT, Nguyen Huynh DT. At the same time, the single arm study was included in the analysis, not involved in data synthesis, only used to assist in displaying the clinical characteristics of the subjects, not for efficacy evaluation. Articles in Google Scholar by Xiaolin Zhang, MD, Other articles in this journal by Xiaolin Zhang, MD, Intermediate dose cytarabine improves survival and relapse-free rate compared with standard-dose cytarabine as post-remission treatment for acute myeloid leukemia: A retrospection study, Privacy Policy (Updated December 15, 2022). How to take it to realize the maximal efficacy? The secondary outcomes of this review will include antipyretic time, disappearance rate of fever symptoms, disappearance rate of cough symptoms, disappearance rate of asthenia symptoms, and adverse drug events. Avoid cigarettes, alcohol and keep from eating spicy, raw, cold or greasy food. The proportion of severe patients admitted to covid-19 hospital is 15.7%, and the death rate of confirmed patients is 6.7%. Clinical observation shows that the total effective rate of traditional Chinese medicine is >90%.[15]. Before the successful development of targeted vaccine, >4 million patients with covid-19 and asymptomatic infection around the world may also benefit from traditional Chinese medicine such as Lianhua Qingwen. Why is it important to subscribe? Medicine. ACTSmarket.com is the e-shop and distribution arm of ACTSmarket Ltd, eCollection 2023. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment course. The patients receiving Lianhua Qingwen Capsule treatment were assigned to the observation group (n=33) and those given conventional therapy were included in the control group (n=33). The Daily Guardian is a renascent Iloilo-based publishing firm and media outfit with bureaus in Kalibo, Boracay, Roxas, Bacolod, Antique, Guimaras, and Manila. The PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) checklist of this protocol is presented in PRISMA-P checklist. Pharmacological experiments have indicated that a high dosage of Lianhua Qingwen alters the effectiveness of cyclooxygenase-2 in the arachidonic acid metabolic pathway and >10 to <14 years old: 3capsules x 3 times a day ( after breakfast, lunch and dinner).> 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). Abbreviations: BAs = comparison before and after the study, C0VID-19 = Corona Virus Disease 2019, ChiCTR = China Clinical Trial Registration Center, MERS = Middle East respiratory syndrome, NOS = Newcastle Ottawa scale, NTR = Netherlands National Trial Registration Center, PRISMA-P = Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, RCTs = randomized controlled trials, RCSs = retrospective cohort study. For the treatment, the main effects of Lianhua Qingwen Jiaonang capsuleare as follows: First, after taking the capsule, patients' symptoms improve quickly, recovery rate up to 91.5%, conversion to severe cases down to 2.1%. Add your comment to start the conversation. [17]. There is no effective antiviral drug for COVID-19. Please try after some time. Ding Y, Zeng L, Li R, et al. Wu Yiling. Experimental study on the anti Coxsackie B4 virus effect of Lianhuaqingwen capsule [J]. Molecules. 94d329df351d7da8aefc2.shtml, https: //www.who.int/docs/default source/coronaviruse/situation-reports/20200325-sitrep-65-, https://www.jiyinzaixian.com/news/bNu5eb13ba6806e0, http://www.xinhuanet.com/politics/2020-03/24/c_1125757251.htm, http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml. When the dose was administered at 150, 300, and 600 g/mL, it significantly inhibited the expression of SARS-CoV-2 in a dose-dependent manner, and inhibited the formation of plaques in virus-infected cells, confirming that Lianhua Qingwen significantly inhibited SARS-CoV-2 activity in vitro. [34]. To systematically determine the effect of Lianhua Qingwen Capsules on the early antiviral and anti-inflammatory action against COVID-19 (Coronavirus 2019) and its applicational value in the treatment of COVID-19. 3.Patients with common cold due to wind-cold dont apply to the product. Shunya Zhu, Xiaoying Li, Yunling Wei, et al. Effect of Lianhuaqingwen Capsule on lung pathological injury and expression of inflammatory factors in mice induced by automobile exhaust [J]. Statistical analysis was conducted by Revman 5.3 software. Led by Iloilos most respected journalists, the Daily Guardian pledges to tell the Ilonggo story as seen through the various lenses of society so that every side may be told. For oral use after meals,4 capsules thrice daily or by medical ordor5 boxes for a treatment If I2 test 50%, a random-effects model will be used for data analysis instead. Asia's one-stop resource for medical news, clinical reference and education, Click to view Lianhua Qingwen detailed prescribing information. The capsule was earlier developed in 2003 to treat the severe acute respiratory syndrome (SARS) and extracts the essence of 13 herbs. [29]. In 2011, Diagnosis and Treatment Guide for Influenza (2011), issued by the Ministry of Health National Bureau of disease control and prevention. Below dosage is a guide only. Progress in pharmacology and clinical research of Lianhuaqingwen capsule [J]. Its formulation includes 13 herbs which are said to have been used for medical purposes as early as the Han dynasty. If you buy two boxes at a time, or an integral multiple of two boxes (such as 4 boxes or 6 boxes), we will give you one box for every two boxes. [3] It is reported that 4,430,100 cases have been confirmed in the world, and 299,451 cases have died. The Chinese embassy likewise advised the public to only purchase and consume authentic traditional Chinese medicine produced by qualified pharmaceutical manufacturers. Copyright Shijiazhuang Yiling Pharmaceutical Co,Ltd. [27]. Subgroup analysis and sensitivity analysis will be performed to explore the causes of heterogeneity. XLZ and JNL will assess the risk of bias and perform data synthesis. Hongtao Lei, Shutu Ma, Xiuxin Jiang, et al. may email you for journal alerts and information, but is committed [12]. Careers. > 5 to <12 years old: 2 to 3 capsules x 3 times a day ( after breakfast, lunch and dinner). Statistical heterogeneity will be assessed with the I2 statistic. Henan traditional Chinese medicine 2007;27:356. For NRIs, evaluate its methodological quality with the Newcastle Ottawa scale (NOS). Copyright 2023 MIMS Pte Ltd. All rights reserved.
