i been suffering for close to a year from just 3 weeks of usage. Episode 18. And the interesting thing is that the average age of this group was 32 to 34 years old This drug for young men must be taken off the market. Etc Etc Epub 2022 Jan 10. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain: Neuroendocrinology, Dec. 9, 2015. Two papers in a short period of time showing higher rates of suicide with finasteride. Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent? November 13, 2020. Re: Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians. Additional side effects of finasteride include: A low DHT state can lead to low dopamine (R), high estrogen (R), high prolactin (due to reduced dopamine), high cortisol (due to reduced clearance) (R), elevated serotonin (due to elevated estrogen and lower dopamine) and hypothyroidism (R). Thanks in advance. Theoretically, you are going to block the production of hormones that serve very important behavioral purposes. Yuck. Based on data of this study, I will strong[ly] recommend to my patients [that] using finasteride has the probability of suicidehigher than 22% than no use. In addition, there is a recognized conglomerate of sexual side effects accompanied by neuropsychiatric effects including depression that have been grouped into a term known as post-finasteride syndrome. So far I tread Clomid and nolvadex cycles but I only had one day where libido returned, rest of time didnt feel anything good or bad when on it. ). I have personally seen in my practice otherwise completely healthy young men who come in for ED and the only medication they had taken was finasteride for hair loss. Literally a drug looking for any reason to still exist. Diviccaro S, Giatti S, Cioffi L, Falvo E, Herian M, Caruso D, Melcangi RC. Pills for Hair Growth: YouTube, June 2022. The .gov means its official. and transmitted securely. Importantly, adverse effects associated with finasteride can persist even after discontinuing its use, leading to what has been termed post-finasteride syndrome, including sexual, physical, and psychiatric symptoms, including depression, anxiety, cognitive impairment, and suicidal ideation. Hundreds of patients coming to #sandiegosexualmedicine with this. From frail and hypogonadal, to gaining 60lbs of muscle, boosting testosterone over 1,000ng/dl and becoming a successful entrepreneur. Epub 2018 Oct 6. In the last decade, concerns have emerged around finasteride, a drug used for treating male-pattern baldness and prostate gland enlargement. Prostatis Blocking 5 alpha-reductase to any degree in the brain is a crapshoot. Moreover, the effects persisted long after the drug had been discontinued.[T]hey then called in men with PFS, took skin from the penis and found that the density of androgen receptors in men with PFS was about twice that of those without. It can be reversed yes. Persistent sexual side effects of finasteride: could they be permanent? Federal government websites often end in .gov or .mil. Observations performed in a subset of patients treated for male pattern hair loss indicate that persistent sexual side effects as well as anxious/depressive symptomatology have been reported even after discontinuation of finasteride treatment. VigoraClinic.com, April 30, 2020. Optimize thyroid. May 21, 2019. (English version): 66 Minutes, Feb. 3, 2019, Persistent adverse effects development from finasteride in young men include erectile dysfunction, low libido, lack of orgasm and depression. In evaluating fertility, how do you counsel men taking finasteride for hair loss? Results are up! Response via Twitter to statements about the Prostate Cancer Prevention Trial concluding that 5-ARIs can cause prostate cancer: May 2022. It is not known why some men are susceptible to the potential adverse effects of finasteride, while othersthe majorityare not affected.Further research is needed on who is susceptible to the persistent, adverse side-effects of finasteride and on the underlying mechanisms of the medication. It's real alright. Hello. [E]very day I receive more and more emails from young men whose lives have been changed by finasteride. They also have problems with sex drive. Finasteride is phasing out of my practice. In 2021, an international group of doctors and researchers published diagnostic criteria for post-finasteride syndrome. Acufene You might thus benefit from things that stimulate bile flow such as taurine and TUDCA. I will start Progesterone cream with tongkat ali soon. Some of these same doctors and researchers are also members of our Medical Professionals team, counseling PFS patients and their loved ones worldwide. Aim: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. My hypothesis is that finasteride can cause brain damage which needs to be reversed. Thanks. Never mind mess with my precious and pleasant DHT. Hey Peterson, Utah Mens Health YouTube channel: July 11, 2019. What is post-fin syndrome anyway? I have seen some cases of post-finasteride-syndrome that do not revert to anything. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics: November 2021. Would you like email updates of new search results? Thanks for the positive feedback and Im glad its helpful. Direct Healthcare Professional Communication letter, October 4, 2018. The brain fog has never gone away. What do you think of TRT is PCT to recover from PFS? Essentially, the cells get too much DHT, it puts them in overdrive and it burns them out. I will not prescribe finasteride to young men with MPB because of the potential side effects. You can argue with the theoretician but you cant argue with the anecdotal stories of successful recovery. Bile also acts as an anti-bacterial and anti-microbial substance which keeps the gut clean and prevents SIBO and SIFO. Emerging post-marketing reports of persistent depression and sexual side effects have led to growing concerns about the safety of 5-reductase inhibitors and prompted product labelling changes in many regulatory jurisdictions.1234 Since 2008, at least 17 countries including the United Kingdom and the United States have warned prescribers of the potential for depression, sexual side effects, or both with finasteride.5, Post-finasteride syndrome is an ill defined and controversial syndrome associated with a constellation of sexual, physical, and psychological symptoms that develop during or after finasteride exposure and persist after discontinuation (box 1).35 The incidence of post-finasteride syndrome is unknown, as are the biological mechanisms, but we know that 5-reductase inhibitors reduce synthesis of brain neurosteroids, which affect mood, cognition, and libido.36. This site needs JavaScript to work properly. Finasteride 1 mg in Alopecia: Sexual Dysfunction, Suicidal Ideation: Prescrire, October 2016, In this pilot study, we sought to characterize sexual and nonsexual adverse effects that men reported experiencing at least 3 months after stopping the medication.Responses from 131 generally healthy men (mean age, 24 years) who had taken finasteride for male pattern hair loss was included in the analysis. What do you think about proviron and other DHT derived steroids? Published by Elsevier Inc. All rights reserved. But always do blood tests first to see what is really going on. 2022 Oct;11(10):1452-1457. doi: 10.21037/tau-22-92. Its always been a question in my mind: Was this a lingering drug effect, or are there other factors coming into play? [W]e also need to stop prescribing finasteride. I recovered and I hope all of you suffering from PFS recover too. Sexual Problems of Men With Androgenic Alopecia Treated With 5-Alpha Reductase Inhibitors. As the name suggests, PFS is most commonly associated with finasteride, which was licensed for the treatment of male pattern baldness in 1997. The patient needs to know that, and to be able to say, Im stopping now. Twenty percent of men who take Propecia see their sexual function diminish. Some might be upregulated and some downregulated, so you might experience heightened serotonin responses. Before Signs of post-finasteride syndrome (PFS) include mood swings, mental fog, depression, anxiety, erectile dysfunction, orgasm and ejaculation dysfunction. Did you check your estrogen before and after? Rzeszotek S, Kolasa A, Pilutin A, Misiakiewicz-Has K, Sielatycka K, Wiszniewska B. Biomedicines. Cannibus is my only vice, so any suggestions would be greatly appreciated. Insomnia and fatigue/tiredness were some of the most debilitating symptoms Men under 40 years of age who use finasteride for alopecia are at risk of suicide if they develop persistent sexual adverse effects and insomnia. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment.The most frequent sexual symptomswere loss of penis sensitivity (87.3%), decreased ejaculatory force (82.3%), and low penile temperature (78.5%). [PFS] appears to occur in sensitive individuals, even if exposed to small doses and for short periods, and symptoms can persist for long periods. Muscle pain Four clicks per day at .25 mL each. (2009) of 2017. Suicidality and Psychological Adverse Events in Patients Treated with Finasteride. and transmitted securely. 2022 Jul-Aug;24(4):390-397. doi: 10.4103/aja202171. Here is how you focus specifically on increasing allopregnanolone: The optimal range for estrogen is around 20pg/ml and if yours is much higher, it would be best to make it a priority to lower it. I strong[ly] agree with you, using p=0.06 to [say] that no association between suicide and finasteride is a very careless decision. They barely help LUTS, cause bad sexual side effects, cause false reassurance in those with an elevated/rising PSA, and now this. Post-finasteride syndrome is an ill defined and controversial syndrome associated with a constellation of sexual, physical, and psychological symptoms that develop during or after finasteride exposure and persist after discontinuation (box 1). Hi Gary, 2023 Mar 21;24(6):5904. doi: 10.3390/ijms24065904. Topical TRT will increase DHT even more. Clipboard, Search History, and several other advanced features are temporarily unavailable. Based on currently available data, the use of 5-reductase inhibitors in patients with a history of depression, sexual dysfunction or infertility must be carefully and individually evaluated. Markthceck (SWR TV) Lifestyle Drug Finasteride: Dead pants instead of a bald head? To date there are no predictive factors for the risk of development of post-finasteride syndrome and no known treatment for the disorder. Hi man, what have you done so far that helped you to 80% recovery? Limited research exists exploring the psychological corollaries of post-finasteride syndrome and preexisting Axis I and Axis II mental health conditions. Expanding (via Twitter) on a study published in JAMA Dermatology he co-authored, titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, December 7, 2020. What few people know is that there are 5-R and 3 types of 5-R enzymes and that theyre not only involved in the conversion of testosterone to DHT, but also in the: Many of the benefits of testosterone, such as enhanced insulin sensitivity, reduced catabolism, higher dopamine, increased thyroid hormone production, are mediated by DHT, and blocking DHT production prevents those effects/benefits. A Comment on the Post-Finasteride Syndrome. Only individuals who are born with intersex characteristics (hermaphrodites) have low levels of this hormone. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women, Post-finasteride syndrome: a surmountable challenge for clinicians, Direct Healthcare Professional Communication letter, BioBalance Healthcast: The Ugly Truth About Finasteride. Epub 2012 Jul 12. Post-Finasteride Syndrome: An Underestimated Phenomenon: Urology and Andrology, September 2016. Whats happening to the progesterone if I try HCG? An observational retrospective evaluation of 79 young men with longterm adverse effects after use of finasteride against androgenetic alopecia: Androlog, Jan. 13, 2016. Playing with your sex hormones with Propecia use can play with your sex life: Pelvic Health & Rehabilitation, July 16, 2015, Nowadays some young men prefer to take fina[steride] AND duta[steride] to try to keep their hair. [T]here is no known treatment for lifelong PFS. The .gov means its official. Do not use finasteride (Propecia, Proscar) for hair loss. In addition, many doctors dont understand or even recognize PFS as a real disease and these patients will suffer alone. I just picked up Gaba, im assuming this is a good idea? Thats a very common thing. Sant report on the suicide of PFS patient Romain Mathieu: France 5 News, Nov. 24, 2016. Does stopping treatment mean the physiological mechanism of testosterone secretion is reset? The effect of finasteride on dry eye disease, Investigative Ophthalmology & Visual Science, Playing with your sex hormones with Propecia use can play with your sex life, Statement (via Twitter) to medical colleague, Risk of Depression Associated With Finasteride Treatment, Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, Statement (via Twitter) in response to Jagan Kansal, MDs tweet, Thoughts on propecia in young guys causing decreased libido, possibly permanent?, Response (via Twitter) to the top 20 adverse reactions to finasteride filed with the FDA, Taking Propecia or Proscar to Prevent Hair Loss is Associated with Depression, Anxiety, and Sexual Problems, Response via Twitter to the Karolinska Institutet study Association of 5-Reductase Inhibitors With Prostate Cancer Mortality, Response (via iCliniq) to the mother of a 23-year-old male whose dermatologist prescribed finasteride, Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics, Post-Finasteride Syndrome: An Underestimated Phenomenon, Challenge to fellow health professionals via Twitter, Post-Finasteride Syndrome: Efforts to explain persistent symptoms are undermined by poor long term data on harms, Reaction (via Twitter) to publication of the study Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, in JAMA Dermatology, Successful Finasteride Treatment Can Lead to Permanent Problems, Statement (via Twitter) in response to a study titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride, Expanding (via Twitter) on a study published in JAMA Dermatology he co-authored, titled Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride. Zhang JJ, Shi X, Wu T, Zhang MD, Tang J, Yin GM, Long Z, He LY, Qi L, Wang L. Asian J Androl. Post-finasteride syndrome is a non-medical term used to describe a variety of side effects reported by some people who've taken finasteride. Post-finasteride syndrome is a serious state of permanent sexual, mental and physical side effects which do not resolve after quitting the drug It is also surmised by the few specialists in the medical field that a type of receptor or brain damage has occurred.Men suffering from PFS are plagued with many physical, mental, and emotional symptoms that have led to long-term depression, marital problems and divorce, and now several reported cases of suicide. I cant answer. Stop finasteride: 45.6% As I read websites like yours and CDsNuts. Therefore, the effects of a subchronic treatment of finasteride.have been evaluated in male rats. One month after the last treatment.changes in neuroactive steroid levels, steroid receptorsand GABA-A receptor subunitswere detected. It is frequently marketed as androgen deprivation therapy for treatment for male pattern baldness. Swiss TV network SRF, May 7, 2018. Yes After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome All my symptoms have subsided and improved with this method which takes a while but I am fully functional It's H.C.G (HCG) dosed at 250IU Monday, Wednesday and Friday only. I have hundreds of [PFS] patients. I think its a combination of low energy production due to cellular damage and excess ROS production. I will never prescribe finasteride. Love the site. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. However, the side effects of a medication usually go away when you stop taking it. been putting it off, but this convinced me to see a doctor and gives me hope. FOIA A few good ways to lower serotonin include: For a more comprehensive guide on lowering serotonin, check out this article: Apart from just focusing on hormones and neurotransmitters, you can also focus on diet and lifestyle. Unauthorized use of these marks is strictly prohibited. My total t is 650 ng/dl. 2012 Nov;9(11):2927-32. doi: 10.1111/j.1743-6109.2012.02846.x. Any other advice that would help is greatly appreciated. Letter to the PFS Foundation, March 2, 2022. Some recommend andractim, available in Europe (and online). Health Canada recently recommended adding a warning to products containing [finasteride] While being administered the above-mentioned drug, patients may develop muscle weakness and stiffness, which in turn may cause pain to the patient, damage to muscle tissue and an increase in kinase enzymes. If so you might have reduced bile flow. Published reports of clinical trials provide insufficient information to establish the safety profile for finasteride in the treatment of AGA. Mechanisms of finasteride So let's discuss what the drug, finasteride, does in the first place. If a patient treated with 1 mg finasteride develops psychiatric symptoms, treatment should be stopped. The use of Finasteride (Proscar) for the prevention of cancer is limited since it only prevents the harmless type of prostate cancer (the SKY Stage.) I dont think its very responsible for dermatologists to use [finasteride] to combat hair loss. Epub 2020 Jun 26. Is This Hair-loss Drug Dangerous? Do tests to see pregnenolone, progesterone, testosterone, DHT, thyroid (TSH, total and free T4 and T3, rT3), estradiol, estrone-sulfate and cortisol (both blood and 24h saliva). Avoid all environmental plastics and toxins, Cold and hot exposure, such as swimming in a cold river and doing sauna sessions. As yet, the condition is not recognized by the medical community, although individuals who suffer from PFS present with relatively homogenous symptoms. There is not a lot of (if any) scientific evidence to backup this up yet, but that doesn't mean that it's non-existent. Accessibility 8600 Rockville Pike BioBalance Healthcast: The Ugly Truth About Finasteride, June 7, 2021. The longer they take it, the greater the risk of experiencing persistent side effects, including after theyve stopped. My blood level are ok only progesterone and colesterolo are higher than the max range. Post-finasteride syndrome (PFS) is still controversial in the medical world. Fertil Steril. 2021 Dec 13;54(4):422-434. doi: 10.1055/s-0041-1739254. Heres how to prevent it, Super T Performix review: Ineffective because, BPC-157: a super peptide for erectile dysfunction, Does weed make you horny? Patients should be informed of these risks, so that they can weigh the benefits of harms against treatment. Post-finasteride syndrome - does it really exist? They have low libido. Seen this far too often to doubt that its real. HHS Vulnerability Disclosure, Help Treatment of young subjects is of increasing concern due to accumulating evidence that daily use of oral finasteride has several severe adverse effects.Since finasteride inhibits T conversion into DHT, which is responsible for most androgen activity, it is plausible that prolonged finasteride use in predisposed individuals could simulate the effects of aging in young men. If I work out too much or my job is extra stressful I become symptomatic. The Impact of 5-Reductase Inhibitor Use for Male Pattern Hair Loss on Men's Health. Thus, it is inappropriate to dismiss this condition. This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. In my opinion, I do not recommend using finasteride for the treatment of hair loss as its side effects are more dangerous. Do explosive exercises, such as uphill sprints, muscle-ups, jump squats, burpees, etc. Sexual dysfunction and suicidal ideation that appears to result from [finasteride] are important adverse effects. BPH? Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia: Journal of Sexual Medicine, November 2016. Persistent erectile dysfunction in men exposed to the 5-reductase inhibitors, finasteride, or dutasteride: PeerJ, March 9, 2017. It just means that you might have to implement certain strategies and use certain supplements for quite some time before the enzymes normalize. You can send me an email at menelite101@gmail.com with your labs (and any addition info you might deem relevant) so I can take a look. One key indisputable clinical evidence noted in all reported studies with finasteride and dutasteride was that use of these drugs is associated with development of sexual dysfunction, which may persist in a subset of men, irrespective of age, drug dose or duration of study. Hair Loss Drug Under Fire For Sexual Side-Effects: CBS 2 News Chicago, May 11, 2011. These drugs are poison. I wanted to take a minute to talk to you about post-finasteride syndrome since more and more men are coming in with complaints after taking finasteride. A group of Italian researchers gave finasteride to rats and noticed that the number of androgen receptors in their brains went up. The Virility Paradox: The Vast Influence of Testosterone on Our Bodies, Minds, and the World We Live In: February 2018. Post finasteride syndrome and adrenal fatigue can be interrelated. Keep sexual side effects in mind! The https:// ensures that you are connecting to the In my clinical experience, the length of time on the medication does not correlate with the severity or duration of the side effects. The Interplay between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation. FDA is concerned that use of finasteride by pediatric patients may pose long-term safety risks regarding growth, development and sexual function. Have you tried getting loads of sunlight? Bone pain Learn how your comment data is processed. We propose that the Dermatologist Society remove from their guidelines the utilization of finasteride for male pattern hair loss., Sexual and Nonsexual Problems after Finasteride Used for Hair Loss in Young Men: American Society for Mens Health, 2014. Discover, October 2020. Any idea why that may be? Maksym et al., Post-finasteride . With that in mind, DHT can take anywhere from4 weeks to 2 years or more to recover(R). Hi David, 2019 Apr;7(2):277-282. doi: 10.1016/j.sxmr.2018.07.003. The Drug that Banishes Baldness Can Ruin a Mans Love Life: Daily Mail, July 22, 2019. Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens, Psychoneuroendocrinology, October 2016. Transdermal substitution of dihydrotestosterone led to an improvement in sexual symptoms in two placebo-controlled studies. MeSH Statement (via Twitter) in response to study titled Long-Term Effects of Finasteride on Prostate Cancer Mortality, January 29, 2019. Responding, via Twitter, to the study Association of 5-Reductase Inhibitors With Dementia, Depression, and Suicide: December 24, 2022. Based on the existing body of evidence in the contemporary clinical literature, the author believes that finasteride and dutasteride induce a constellation of persistent sexual, neurological and physical adverse side effects, in a subset of men. Eggs vs Whey protein: just stick to this one, Ashwagandha vs Shilajit: the best one for testosterone is, Maca vs tongkat ali: this one is better for libido. Some say its all in the mind, a made-up mythbut those who suffer from it surely know theyre not just a hypochondriac. I started losing hair about 18 yrs old if that helps, Hi I got post finasteride syndrome like side effects from saw palmettherbal blend of dht natural inhibitors from amazon https://www.amazon.com/product-reviews/B004PVLWW0/ref=acr_dp_hist_2?ie=UTF8&filterByStar=two_star&reviewerType=all_reviews#reviews-filter-bar and i did blood work (rosch eclia methodology) but endos cant find anything that could cause all the side effects im dealing with. We recommend patients who have already submitted a report submit a new one using this reaction type. 2022 Oct 27;10(11):2725. doi: 10.3390/biomedicines10112725. The best sex strains. Medications Most Commonly Associated With Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database. Physicians treating male pattern hair loss should discuss with patients the potential risk of adverse events with finasteride. Sure man. Then they have no ejaculate. Post-finasteride syndrome. At least 5-6 patients per year find their way to #UCLA_Andrology. FOIA Some men appear initially to tolerate finasteride or dutasteride, with adverse effects arising weeks, months or years after starting the drug. If estrogen is high, focus on lowering that, as estrogen is a potent inducer of serotonin and prolactin. Organizations such as the Post-Finasteride Syndrome . An observational retrospective evaluation of 79 young men with long-term adverse effects after use of finasteride against androgenetic alopecia. PFS isnt fun. SperlingProstateCenter.com, Aug. 30, 2018. . No Fun. HCG increased my anxiety. no libido No Fun. You do think that these hypothetical damages can be reversed ? You have to choose between hair and sex drive and your personality and your marriage or your partnership Ive tried giving testosterone to patients who are on finasteride at the same time. It can prevent hair loss and decrease prostate enlargement, but not surprisingly, it can also suppress sexual function. PMC There are currently no satisfactory treatment options for post-finasteride syndrome. [A]pproximately 30 million young men, worldwide, would be prescribed finasteride or dutasteride to treat male pattern hair loss. 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. I took and i am taking many of the supplements listed with no real improvements. Finally, the study recommended that finasteride should not be administrated as treatment for androgenetic alopecia in women. Although, they would like you to believe testosterone replacement is the only solution to make a full recovery. Ten years ago, I would have answered differently.
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